Effectiveness of naproxen in laparoscopic sterilization: a double blind randomized placebo controlled study

Effectiveness of naproxen suppositories on ambulation was studied following laparoscopic sterilization. In a double-blinded randomized placebo study, 20 patients received 500 mg naproxen suppositories and 20 patients placebo suppositories. Postoperatively 10 naproxen patients and 11 placebo patients reported high pain scores, indicating severe pain and requiring opiates. Times to reach street fitness were equally prolonged in both groups. Most patients in both groups required 3 days to resume normal duties and post-discharge weakness was a common complaint. Our conclusion was that premedication with naproxen 500 mg suppositories in day-case laparoscopic sterilization therapeutically behaves like other commonly used nonsteroidal anti-inflammatory drugs (NSAI Ds) and does not substantially contribute to ambulation.